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O gene anti-envelhecimento mostra que rebobina a idade do coração em dez anos

Associados a uma longevidade excepcional, portadores de genes mutantes saudáveis, como os que vivem em zonas azuis do planeta, muitas vezes vivem até 100 anos ou mais e permanecem com boa saúde. Estes indivíduos também são menos propensos a complicações cardiovasculares. Os cientistas acreditam que o gene ajuda a manter seus corações jovens, protegendo-os contra doenças ligadas ao envelhecimento, tais como a insuficiência cardíaca.

Neste novo estudo, os pesquisadores demonstram que um destes genes mutantes saudáveis, anteriormente provado particularmente freqüente em centenários, pode proteger as células coletadas de pacientes com insuficiência cardíaca que necessitam de transplante cardíaco.

A equipe Bristol, liderada pelo Professor Paolo Madeddu, descobriu que uma única administração do gene mutante anti-envelhecimento interrompeu a decadência da função cardíaca em ratos de meia-idade. Ainda mais notável, quando administrado a ratos idosos, cujos corações apresentam as mesmas alterações observadas em pacientes idosos, o gene rebobinava a idade do relógio biológico do coração pelo equivalente humano de mais de dez anos.

O professor Madeddu, professor de Medicina Cardiovascular Experimental do Instituto do Coração de Bristol da Universidade de Bristol e um dos autores do estudo, explica: «A função do coração e dos vasos sanguíneos é posta em jogo à medida que envelhecemos. No entanto, o ritmo em que estas mudanças prejudiciais ocorrem é diferente entre as pessoas». O fumo, o álcool e a vida sedentária tornam o relógio do envelhecimento mais rápido». Enquanto que comer bem e fazer exercícios retarda o envelhecimento do coração.

«Além disso, ter bons genes herdados dos pais pode ajudar a permanecer jovem e saudável. Os genes são seqüências de letras que codificam proteínas. Por acaso, algumas dessas letras podem sofrer mutações. A maioria dessas mutações são insignificantes; em alguns casos, porém, a mutação pode fazer o gene funcionar pior ou melhor, como para o gene mutante anti-envelhecimento que estudamos aqui em células humanas e ratos mais velhos».

O estudo de três anos também foi realizado em células cardíacas humanas em tubo de ensaio na Itália. Pesquisadores do Grupo MultiMedica em Milão, liderados pelo Professor Annibale Puca, administraram o gene em células cardíacas de pacientes idosos com problemas cardíacos graves, incluindo transplantes, e depois compararam sua função com a de indivíduos saudáveis.

Monica Cattaneo, pesquisadora do Grupo MultiMedica em Milão, Itália, e primeira autora do trabalho disse: «As células dos pacientes idosos, em particular aquelas que suportam a construção de novos vasos sanguíneos, chamadas ‘pericytes’, foram encontradas com menos desempenho e mais envelhecidas. Ao adicionar o gene/proteína de longevidade ao tubo de ensaio, observamos um processo de rejuvenescimento cardíaco: as células cardíacas dos pacientes idosos com insuficiência cardíaca retomaram o funcionamento adequado, provando ser mais eficientes na construção de novos vasos sangüíneos».

Os centenários passam seus genes saudáveis para seus descendentes. O estudo demonstra pela primeira vez que um gene saudável encontrado em centenários poderia ser transferido para pessoas não relacionadas para proteger seus corações. Outras mutações podem ser encontradas no futuro com potencial curativo semelhante ou até superior ao investigado por esta pesquisa. O Professor Madeddu e o Professor Annibale Puca do Grupo MultiMedica acreditam que este estudo pode alimentar uma nova onda de tratamentos inspirados pela genética dos centenários.

A professora Madeddu acrescentou: «Nossas descobertas confirmam que o gene mutante saudável pode reverter o declínio do desempenho do coração em pessoas mais velhas. Agora estamos interessados em determinar se dar a proteína ao invés do gene também pode funcionar. A terapia genética é amplamente utilizada para tratar doenças causadas por genes ruins. Entretanto, um tratamento baseado em uma proteína é mais seguro e mais viável do que a terapia genética».

«Recebemos financiamento do Conselho de Pesquisa Médica para testar a terapia gênica saudável na Progeria. Esta doença genética, também conhecida como síndrome de Hutchinson-Gilford, causa danos ao coração e aos vasos sanguíneos das crianças no início do envelhecimento. Também fomos financiados pela British Heart Foundation e Diabetes UK para testar a proteína em ratos mais velhos e diabéticos, respectivamente».

Annibale Puca, chefe do laboratório da IRCCS MultiMedica e professor da Universidade de Salerno, acrescentou: «A terapia genética com o gene saudável em modelos de doença de camundongos já foi demonstrada para prevenir o aparecimento de aterosclerose, envelhecimento vascular e complicações diabéticas, e para rejuvenescer o sistema imunológico».

«Temos uma nova confirmação e ampliação do potencial terapêutico do gene/proteína». Esperamos testar em breve sua eficácia em ensaios clínicos em pacientes com insuficiência cardíaca».

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